Gap Junctions and Connexin Hemichannels Underpin Haemostasis and Thrombosis
نویسندگان
چکیده
Institute for Cardiovascular & Metabolic Research, School of Biological Sciences, University of Reading, Reading, United Kingdom; Dept of Physiology, University of Arizona, Tucson, AZ; Dept of Cell Physiology & Pharmacology, University of Leicester, Leicester; Centre for Advanced Microscopy, University of Reading, Reading; Cardiovascular Biology Research, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
منابع مشابه
Gap junctions and connexin hemichannels underpin hemostasis and thrombosis.
BACKGROUND Connexins are a widespread family of membrane proteins that assemble into hexameric hemichannels, also known as connexons. Connexons regulate membrane permeability in individual cells or couple between adjacent cells to form gap junctions and thereby provide a pathway for regulated intercellular communication. We have examined the role of connexins in platelets, blood cells that circ...
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Platelets are involved in the maintenance of haemostasis but their inappropriate activation leads to thrombosis, a principal trigger for heart attack and ischaemic stroke. Although platelets circulate in isolation, upon activation they accumulate or aggregate together to form a thrombus, where they function in a co-ordinated manner to prevent loss of blood and control wound repair. Previous rep...
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The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbor connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43. Connexins give rise to hemichannels, which dock with counterparts on adjacent cells to form gap junctions. Both hemichannels and gap junctions provide pathways for communication, via paracrine signalin...
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The normal function and survival of cells in the avascular lens is facilitated by intercellular communication through an extensive network of gap junctions formed predominantly by three connexins (Cx43, Cx46, and Cx50). In expression systems, these connexins can all induce hemichannel currents, but other lens proteins (e.g., pannexin1) can also induce similar currents. Hemichannel currents have...
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تاریخ انتشار 2012